Joe Peters and his partner Butch Shilton have been on the run for a year. On their way to prison for shooting a cheating gambler, a gang of outlaws murdered their escort - a crime for which the pair have been blamed. Trouble follows them everywhere, and they end up in the brutal Los Pecos penitentiary. Breaking out, they flee to Mexico, only to fall foul of the notorious bandit Barca. With enemies closing in on all sides, could this be the end of the trail for Butch and Joe?