"Science journalist Tom Zeller Jr. takes readers on an odyssey both intimate and panoramic, through his own decades-long struggle with cluster headaches and across the scientific landscape of a group of disorders that is -- to the chagrin of sufferers -- as much a curse as a cultural punchline. He visits cutting-edge clinics; interviews dozens of doctors, neurologists, and fellow headache patients; participates in clinical trials for multi-million-dollar new medicines; and even experiments with psilocybin in search of relief. Along the way, Zeller traces the longer arc of mystery around headaches, from prehistoric skull surgery to Virginia Woolf's assertion that, in the throes of a migraine, 'language runs dry,' to reveal how headaches became one of the most under-researched afflictions in medicine -- and how that is slowly starting to change"-- Provided by publisher.