Nancy Evans is a lovely circus owner whose crooked manager, George Ward, sabotages her circus with a series of mysterious incidents. This leaves her with no choice but to sell the ranch her grandfather left her in Mesquite County. Bankrupt and broke, Nancy and her band of carnies decide to move to Mesquite and live on the ranch until they're back on their feet. Ward and is cohorts vow to drive Nancy off her ranch, but standing in their way are Nancy's new neighbors, The Three Mesquiteers.